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Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
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心臓補助システムの試作型離心ポンプローターの生物安全性評価

Przemysław Kurtyka1,2, Justyna Więcek-Chmielarz2, Marcin Surmiak3,4

  • 1Foundation of Cardiac Surgery Development, Institute of Heart Prosthesis, Zabrze 41-800, Poland.

ACS biomaterials science & engineering
|January 1, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
血液物質の相互作用心臓のサポート用のロータステレオリトグラフィー

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...