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Liron Pantanowitz1, Sara E Monaco2, Blythe K Gorman3

  • 1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Journal of the American Society of Cytopathology
|January 1, 2026
PubMed
まとめ

No abstract available in PubMed .

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In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...