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トリプルネガティブな乳がんにおける腫瘍原性変異体TP53の合成致死性機能増強を標的とする高通量RNA干渉スクリーン

Susumu Rokudai1

  • 1Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. srokudai@gunma-u.ac.jp.

Methods in molecular biology (Clifton, N.J.)
|January 1, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
アデノシン受容体高通量RNA干渉スクリーン (HTS-RNAiスクリーン)分子標的がん療法ミュータントTP53トリプルネガティブ乳がん (TNBC)

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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