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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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主要応答中の臓B細胞における体性高変異分析の実験手順

Seth Greene1, Alyssa Fennig-Victor1, Yongwei Zhang2

  • 1Department of Pharmaceutical Sciences, St. John's University, Queens, NY, USA.

Methods in molecular biology (Clifton, N.J.)
|January 1, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
AID についてアクティベーション誘発型シチジンデアミナーゼ適応免疫B細胞受容体BCR について次世代シーケンシング腫瘍生成SHMソマティック・ハイパーミューテーション

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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