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Updated: May 2, 2026

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人間の肝細胞とネズミのモデルを用いた工業的に重要なグラフェン酸化物の毒性評価

Yulli Roxenne Albuquerque1, Ricardo de Oliveira Correia2, Karina Alves Feitosa1

  • 1Laboratório de Inflamação e Doenças Infecciosas, Departamento de Morfologia e Patologia, Universidade Federal de São Carlos, São Carlos, Brazil.

Journal of toxicology and environmental health. Part A
|January 2, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
グラフェン酸化物HepG2 細胞ムス・ムスキュルスナノ材料毒性について

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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