内皮PROX1は,中枢神経系における血脳障壁の破壊を誘発する
Sara González-Hernández1, Ryo Sato1, Yuya Sato1
1Laboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute.
JCI insight
|January 2, 2026
まとめ
No abstract available in PubMed .
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Overview
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Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
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