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溶解性で表現された小型化されたSMART MHCの設計

William L White1,2, Hua Bai2,3,4, Chan Jhong Kim2,3

  • 1Department of Bioengineering, University of Washington, Seattle, WA 98195.

Proceedings of the National Academy of Sciences of the United States of America
|January 2, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
T細胞受容体メジャー・ヒストコンパティビリティ・コンプレックスタンパク質の設計溶性表現

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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...