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Jieyu Zhao1, Kota Kurisu2,3, Kazuki Ohashi1

  • 1Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.

PloS one
|January 2, 2026
PubMed
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No abstract available in PubMed .

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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...