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Updated: May 2, 2026

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
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Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects

Published on: February 18, 2014

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ブルチェラ・アボルトスのバクテリオフェリチンによる構造分析と阻害剤モデリング

Lijun Liu1,2, Elizabeth K Harmon2,3, Justin K Craig2,3

  • 1Protein Structure and X-Ray Crystallography Laboratory, Del Shankel Structural Biology Center, University of Kansas, Kansas, USA.

Proteins
|January 2, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
バクテリオフェリチンブルセロシス抑制剤への結合鉄の輸送病原体タンパク質複合体

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Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
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