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Updated: Jan 7, 2026

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

長読メタゲノムのアセンブリにおける一般的なエラーのトラブルシューティング

Florian Trigodet^1,2, Rohan Sachdeva³, Jillian F Banfield^4,5,6,7,8

¹Helmholtz Institute for Functional Marine Biodiversity, Oldenburg, Germany.

Nature biotechnology

|January 2, 2026

まとめ

No abstract available in PubMed .

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Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

Metagenomic Analysis of Silage

Metagenomic Analysis of Silage

Published on: January 13, 2017

関連する概念動画

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

Genome Copying Errors

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their survival. Therefore, the copying errors are checked and repaired at three levels.

Mismatch Repair

Mismatch Repair