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Updated: Jun 18, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
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Aβプラークは,ヒトのiPSC由来ニューロン異種移植において局所的な前シナプス毒性を誘発する

Jacqueline Fréderique Maria van Vierbergen1, Carles Calatayud1, Sriram Balusu1

  • 1VIB KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium.

Stem cell reports
|January 3, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
アルツハイマー病アミロイドベータプラークディストロフィック・ニューライト細胞外Aβ前シナプスシナプス毒性異種移植

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Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...