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Updated: Jan 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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持続性腫瘍細胞におけるオープンクロマチンシグネチャの単細胞解像度

Mihai Gabriel Dumbrava1, Wazim Mohammed Ismail2, Leticia Sandoval3

  • 1Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Mayo Medical Scientist Training Program, Mayo Clinic, Rochester, MN, USA.

Cell reports
|January 4, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
CP: がんについて化学療法に対する耐性クロマチンのアクセシビリティ高度卵巣がんオープンクロマチン患者からの異種移植持続性のある細胞のサイン単核マルチオミック

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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