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Updated: Jan 7, 2026

Oligopeptide Competition Assay for Phosphorylation Site Determination
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ProtPSP: タンパク質大言語モデルによるタンパク質リン酸化部位の決定

Bifeng Guan1, Lei Guo1,2, Thomas Ka-Yam Lam3

  • 1College of Computer and Data Science, Fuzhou University, Fuzhou 350108, China.

ACS omega
|January 5, 2026
PubMed
まとめ

No abstract available in PubMed .

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Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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