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Updated: Jun 15, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

425

マウスにおけるcGASノックアウト抑制性エンドトキシン誘発性ウベイト

Yue Guo1,2,3,4,5, Ruiping Gu1,2,3,4, Jiaojiao Wei1,2,3,4

  • 1Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.

Genes & diseases
|January 5, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
EIU についてリポポリサッカリド網膜スティングcGAS について

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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
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