ソフトスプレーによるサンドイッチバイオマスフィルムの作製と薬物放出制御

Natural polymer gel films exhibit excellent biocompatibility, biodegradability, and low cost and are widely used in the development of biomedical materials. In this work, we utilized a soft-spray-assisted technique to construct sandwich-structured gel films (G-B-G) via layer-by-layer assembly at the miscible quasi-interface by taking advantage of the rapid gelation properties of natural polymers and the superiority of soft spray technology. Tetracycline was first incorporated into the guar gum/boric acid gel film, which was subsequently encapsulated with a Gel-ADH/HA-CHO gel film. The resulting G-B-G gel films have been demonstrated to effectively regulate the release performance of tetracycline, significantly mitigating the initial burst release phenomenon. The initial drug release range (38-82%) can be precisely controlled by adjusting the monomer content to meet different requirements. Furthermore, the drug release mechanism is molecular diffusion, which is consistent with first-order kinetics (R² > 0.99). This enhanced performance is primarily attributed to the sandwich structure acting as an effective barrier for drug diffusion.