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Updated: Jan 13, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

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週1回の血液吸着療法を血液透析濾過療法に追加することによる難治性レストレスレッグス症候群の有用性：臨床症例報告

Cristian Pedreros-Rosales^1,2, Gonzalo Ramírez-Guerrero^2,3, Hans Müller-Ortiz^1,2

¹Departamento de Medicina Interna, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.

Seminars in dialysis

|January 6, 2026

Abstract:

Dialysis improves survival in kidney failure but does not effectively remove larger uremic toxins, contributing to persistent symptoms like restless legs syndrome (RLS). High-volume hemodiafiltration (HDF) has improved these issues, but refractory cases may require combined therapies with hemoadsorption (HA). We present a patient with refractory RLS treated with HDF plus hemoadsorption using Jafron HA130 cartridges. The β2 microglobulin (β2M) reduction ratio was higher during HDF+HA (76.4% [75.8-77.8] vs. 72.9% [71.1-73.2]), with further improvement at Q_B > 400 ml/min (77.6% [77.2-79.4]). Despite similar baseline β2M levels, the patient's RLS score dropped from 32 to 0 points. Adding once-weekly hemoadsorption to high-volume HDF using HA130 adsorption may enhance refractory uremic symptom management, particularly at higher Q_B values. Given the scarce literature on this approach, our case highlights its potential benefits for dialysis patients with persistent uremic symptoms.

キーワード:

β2ミクログロブリン血液吸着血液透析濾過レストレスレッグス症候群尿毒症

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