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Updated: Jan 13, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
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Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

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二重量子相関電子回転共振法による内在的に乱れたタンパク質における変異誘発型変化の検出

Aritro Sinha Roy1,2, Karen Tsay3, Peter P Borbat1,2

  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, United States.

Journal of the American Chemical Society
|January 6, 2026
PubMed
まとめ

電子回転共鳴 (ESR) 脈動二極スペクトロスコーピーは,二重量子相合性 (DQC) を用いてタンパク質の構造を正確にマッピングします. この方法は,ワイルド型と変異型タウタンパク質の断片間の明確な形状の違いを明らかにし,神経変性疾患の研究を支援します.

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