モノリシックセル・オン・メモリスタアーキテクチャにより、バイオリアリスティックな味覚チップのための振動化学受容器のウェーハースケール統合が可能に

Array fabrication and the wafer-scale integration of artificial oscillatory chemoreceptors are crucial for enabling biomimetic chips with bio-realistic chemoreception in practical bioapplications. However, existing chemoreceptors based on conventional architectures require sophisticated or non-scalable fabrication techniques due to inherent material or structural defects. Here we introduce a monolithic cell-on-memristor (CoM) chemoreceptive architecture featuring a unique oscillation mechanism for self-powered biosensing and in situ spike encoding. Through rational material selection and complementary metal-oxide-semiconductor-compatible fabrication, we realize the demonstration of a wafer-scale 10 × 10 CoM array with a spatial resolution of 51 pixels per inch and a very small pixel size of 150 μm, with potential for further scaling down. Using its bio-plausible ion-modulated voltage oscillations with spatiotemporal probabilistic spiking information, we exploit the CoM-array-based gustatory chip to replicate gustation for accuracy salty taste classification. Our CoM architecture offers a general and scalable approach for implementing chemoreceptive oscillatory systems aimed at human-machine biointegration applications.