関連する実験動画

Updated: Jan 13, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

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DNA損傷応答遺伝子と多発性骨髄腫リスクの関連性

Michael Conry1, Irina Ostrovnaya2, Yelena Kemel1

  • 1Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Journal of hematology & oncology
|January 6, 2026
PubMed
まとめ

TP53やATMなどのDNA損傷応答遺伝子（DDRG）の遺伝性変異は、多発性骨髄腫（MM）のリスクを高め、予後不良を予測する可能性がある。この発見は、標的スクリーニングのための高リスク個人の特定に役立つ。

キーワード:
がんの素因となる症候群がん予防がん遺伝学家族性血液悪性腫瘍遺伝的リスク因子生殖細胞系列の素因形質細胞腫瘍まれな病原性バリアントまれなバリアント生存および予後バイオマーカー

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