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Updated: Jan 13, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

免疫グロブリンA腎症患者における腎予後予測における間質性炎症の予測値

Qing Wei¹, Min Wu¹, Yuxiang Gong²

¹Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, No. 87 Dingjiaqiao, Nanjing 210009, China.

|January 7, 2026

要旨

Background:

Renal interstitial inflammation (RII) is a common pathological feature in immunoglobulin A nephropathy (IgAN) and may predict renal outcomes, but further validation is required. This study evaluated the prognostic value of RII and inflammatory cell infiltration in patients with IgAN.

Methods:

This retrospective cohort study included adults with biopsy-confirmed IgAN. Renal interstitial inflammation was categorised as 0 (absent), 1 (around atrophic tubules) or 2 (beyond atrophic tubules). Interstitial CD3⁺, CD20⁺ and CD68⁺ cells were quantified via immunohistochemistry. The primary outcome was a composite of a ≥ 40 % decline in the estimated glomerular filtration rate or end-stage renal disease.

Results:

Of the 112 participating patients, 30 (26.8 %) experienced the primary outcome. A higher RII score was associated with increased risk of progression (hazard ratio for score 2 vs 0: 4.73, 95 % confidence interval [CI]: 2.01-11.13, p = 0.001). Patients with the outcome had higher densities of interstitial CD3⁺, CD20⁺ and CD68⁺ cells at biopsy. Kaplan-Meier analysis showed lower renal survival in patients with higher inflammatory cell densities (p < 0.05). The RII score alone had an area under the curve of 0.804 (95 % CI: 0.715-0.894) for predicting progression, which improved to 0.865 (95 % CI: 0.779-0.951) when combined with the Oxford classification score.

Conclusion:

The severity of RII is independently associated with renal prognosis in IgAN. Immunohistochemical evaluation of inflammatory cell infiltration may improve risk stratification and guide early intervention.

キーワード:

疾患進行免疫グロブリンA腎症炎症細胞浸潤腎間質炎症リスク層別化

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