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ドナー提供の腎結石症:症例に基づく分析と比較研究
Maxwell Sandberg1, Mark Xu1, Randall Bissette1
1Department of Urology, Wake Forest Baptist Medical Center, Winston Salem, NC 27101, USA.
The Canadian journal of urology
|January 7, 2026
まとめ
ドナー提供の腎結石症、または死亡ドナー(DD)腎臓の結石症は、腎移植において非常にまれです。本研究では、患者および移植片の良好な転帰が認められ、結石が既知であっても移植が可能であることが示唆されています。
科学分野:
- 腎臓病学; 移植外科学; 泌尿器科学
背景:
- ドナー提供の腎結石症は、死亡ドナー(DD)腎移植におけるまれな合併症である。既存の研究は限られており、ドナー腎結石管理のための確立されたガイドラインが不足している。このばらつきは、ドナー腎選択とレシピエントケアに影響を与える。
研究 の 目的:
- DD腎移植レシピエントにおけるドナー提供の腎結石症の頻度を決定すること。ドナー提供の腎結石を有するレシピエントにおける患者および移植片の転帰を分析すること。既存の結石を有する腎臓の移植の安全性と実施可能性を評価すること。
主な方法:
- 1979年から2025年までのウェイクフォレストバプテスト医療センターにおけるDD腎移植および術後管理の後ろ向きレビュー。移植中または移植後2週間以内に発見されたドナー提供の結石の同定。治療を受けた患者と経過観察を受けた患者の間での結石径の比較。患者および移植片の転帰の分析。
主要な成果:
- 死亡ドナー(DD)腎移植4723例中8例(0.2%)にドナー提供の腎結石症が認められた。結石の径の中央値は8 mmであった。患者の38%が治療を受け、62%が経過観察を受けた。移植片不全はレシピエントの25%に発生し、1例は結石治療に関連していた。
結論:
- ドナー提供の腎結石症は、DD腎移植において例外的にまれである。良好な患者および移植片の転帰は、既知の結石を有するDD腎臓の移植の実施可能性を支持する。さらなる研究により、このまれな病状の管理戦略が洗練される可能性がある。
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