原発性節外性および非定型リンパ腫における18F-フルオロデオキシグルコースPET/コンピューテッドトモグラフィーの診断的および予後的意義

This study aimed to evaluate metabolic activity profiles of extranodal and atypical lymphoma lesions detected by 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT), and to elucidate the predictive value of this modality in the diagnostic and prognostic workflow.

Seventy-four patients diagnosed with lymphoma underwent 18F-FDG PET/CT. Patients aged greater than or equal to 60 years had significantly higher mean maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean) values. Lesions larger than 2 cm showed significantly elevated SUVmean values. In patients over 60 years, nodal SUVmax was also considerably higher. The SUVmean of extranodal lesions was significantly higher in female patients. A positive correlation was found between extranodal lesion SUVmax and both lesion size and nodal SUVmax.

The significant increase in SUV values with advancing age and larger lesion size, along with the high sensitivity of 18F-FDG PET/CT in detecting distant organ involvement such as bone marrow, highlights its potential to reflect tumor behavior. The observed sex-related metabolic differences further emphasize the need for individualized imaging strategies.