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関連する概念動画

Diagnosing Acidosis and Alkalosis01:24

Diagnosing Acidosis and Alkalosis

1.0K
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2  and...
1.0K
Acid-Base Balance01:25

Acid-Base Balance

2.2K
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
2.2K
Disorders of Acid-Base Balance01:29

Disorders of Acid-Base Balance

1.8K
The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
1.8K
Acid&#8211;Base Titration: Overview01:26

Acid–Base Titration: Overview

17.3K
An acid-base titration is a technique used to determine the concentration of an unknown acid or base, using a titrant of known concentration–either a base for acid titration or an acid for base titration. The process involves gradually adding the titrant, leading to a predictable change in the pH of the solution. This change is plotted on a titration curve, showing how a solution's pH varies with the amount of titrant added. Such curves are instrumental in monitoring the...
17.3K
Bronsted-Lowry Acids and Bases02:58

Bronsted-Lowry Acids and Bases

103.1K
The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
103.1K
Titration of a Weak Acid with a Strong Base01:30

Titration of a Weak Acid with a Strong Base

4.3K
In titrating a weak acid with a strong base, different calculation methods are applied at various stages. Initially, the pH of a weak acid like acetic acid is calculated using its dissociation constant (Ka) and an ICE table. Upon addition of a strong base such as sodium hydroxide, a buffer forms, and its pH is determined using the Henderson-Hasselbalch equation. As more base is added and the titration reaches the halfway point, the pH becomes equal to the pKa of the acid, indicating equal...
4.3K

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関連する実験動画

Updated: Jan 13, 2026

Measurement and Analysis of Extracellular Acid Production to Determine Glycolytic Rate
06:47

Measurement and Analysis of Extracellular Acid Production to Determine Glycolytic Rate

Published on: December 12, 2015

25.7K

塩基過剰とそれ以降：酸塩基分析における進化する概念

Özge Köner1, Tuğhan Utku1, Kubilay Demirağ2

  • 1Yeditepe University Faculty of Medicine, Department of Anesthesiology and Intensive Care, İstanbul, Türkiye.

Turkish journal of anaesthesiology and reanimation
|January 7, 2026
PubMed
まとめ

塩基過剰（BE）は、代謝性酸塩基平衡障害および集中治療患者の死亡率予測の重要な指標である。単純化された数式により、迅速かつ信頼性の高いベッドサイド評価が可能になり、臨床評価が向上する。

キーワード:
酸塩基平衡スチュワートアプローチ乳酸非生成塩基過剰塩基過剰代謝性アシドーシス代謝性アルカローシス

さらに関連する動画

In vitro Monitoring of Extracellular pH in Real-Time
10:11

In vitro Monitoring of Extracellular pH in Real-Time

Published on: June 3, 2021

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Establishment of an Extracellular Acidic pH Culture System
09:41

Establishment of an Extracellular Acidic pH Culture System

Published on: November 19, 2017

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関連する実験動画

Last Updated: Jan 13, 2026

Measurement and Analysis of Extracellular Acid Production to Determine Glycolytic Rate
06:47

Measurement and Analysis of Extracellular Acid Production to Determine Glycolytic Rate

Published on: December 12, 2015

25.7K
In vitro Monitoring of Extracellular pH in Real-Time
10:11

In vitro Monitoring of Extracellular pH in Real-Time

Published on: June 3, 2021

2.1K
Establishment of an Extracellular Acidic pH Culture System
09:41

Establishment of an Extracellular Acidic pH Culture System

Published on: November 19, 2017

15.3K

科学分野:

  • 集中治療医学
  • 生化学
  • 腎臓医学

背景:

  • 塩基過剰（BE）は、代謝性酸塩基平衡障害および集中治療患者の死亡率予測のための重要なマーカーです。
  • 従来のBE評価は、ヘンダーソン・ハッセルバルヒモデルに依存していました。
  • スチュワートアプローチは、よりメカニズムに基づいた評価を提供しますが、複雑な計算を伴います。

研究 の 目的:

  • 塩基過剰の概念の進化をレビューすること。
  • ベッドサイド評価のためのBEとスチュワートアプローチの統合のための単純化された数式を強調すること。
  • 「乳酸非生成BE」の概念を導入し、説明すること。

主な方法:

  • 塩基過剰計算の歴史的発展のレビュー。
  • スチュワートアプローチとBEの統合に関する議論。
  • ベッドサイドでの使用のための単純化された数学的定式化の説明。
  • 「乳酸非生成BE」の定義と適用。

主要な成果:

  • 単純化されたBEの数式により、より信頼性が高く、詳細で、迅速なベッドサイド評価が可能になります。
  • スチュワートアプローチとの統合により、より包括的なメカニズムの理解が得られます。
  • 「乳酸非生成BE」は、特に腎不全において、固定酸の貯留と乳酸アシドーシスを区別します。

結論:

  • 塩基過剰の進化は、より実用的で情報に基づいた臨床ツールにつながりました。
  • スチュワートアプローチと統合された単純化されたBE計算は、酸塩基平衡障害のベッドサイド評価を改善します。
  • 「乳酸非生成BE」の概念は、腎機能障害のある患者の診断精度を高めます。