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Updated: Jan 13, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

腎細胞癌における内因性レトロウイルスの影響に関する現在の見解

Kathryn H Gessner¹, Mi Zhou², Tracy L Rose^2,3

¹Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Kidney cancer journal : official journal of the Kidney Cancer Association

|January 7, 2026

Abstract:

Human endogenous retroviruses (hERVs) have emerged as a mechanism for tumor development and progression in clear cell renal cell carcinoma (ccRCC). Increased expression of various hERVs has been reported in ccRCC with associated activation of anti-tumor immune responses. Retrospective analysis of hERV expression in human ccRCC tumor tissue may suggest hERV expression may be associated with improved response to immune checkpoint inhibitors. However, the use of expression to predict response is limited by our ability to annotate and detect hERV expression. This review discusses the biology of hERVs, their role in ccRCC, and the possible impact on ccRCC response to immunotherapy.

キーワード:

内因性レトロウイルス免疫療法腎細胞癌

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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Retroviral Scanning: Mapping MLV Integration Sites to Define Cell-specific Regulatory Regions

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Published on: May 28, 2017

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