Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

7.3K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
7.3K
Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

419
The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
419
Stringent Response in E. coli01:23

Stringent Response in E. coli

286
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
286
Bacterial Translocation and Protein Secretion01:26

Bacterial Translocation and Protein Secretion

505
Bacterial protein secretion involves translocation systems to ensure proteins reach their designated locations, including the plasma membrane, periplasm, outer membrane, or the external environment. These translocation systems are vital for bacterial physiology, supporting processes like membrane assembly, enzymatic activity in the periplasm, and interactions with the external environment. The division of labor between Sec and Tat pathways ensures efficiency in handling proteins with diverse...
505

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The cholesterol-dependent cytolysin promotes <i>Streptococcus</i> systemic spread and induces arachidonic acid accumulation-mediated lethality in a murine intraperitoneal infection model.

Infection and immunity·2026
Same author

IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice.

Nature microbiology·2026
Same author

Remodeling of tRNA modification in Trypanosoma cruzi life forms.

PLoS pathogens·2026
Same author

Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.

Nature communications·2026
Same author

A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin.

Nature·2026
Same author

IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice.

bioRxiv : the preprint server for biology·2026

関連する実験動画

Updated: Jan 13, 2026

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

11.4K

コレラ菌の血清型が病原性に及ぼす影響

Franz G Zingl1,2,3, Deborah R Leitner1,2,3, Bolutife Fakoya1,2,3

  • 1Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA.

bioRxiv : the preprint server for biology
|January 7, 2026
PubMed
まとめ

小川株のビブリオコレラO1抗原のメチル化は、細菌のコロニー形成と感染性を高めます。このO1抗原メチル化は、抗菌ペプチドから細菌を保護し、小腸での生存を助けます。

キーワード:
コレラ菌O1抗原メチル化小川血清型病原性コロニー形成感染性抗菌ペプチド小腸

さらに関連する動画

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

7.9K
Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

8.8K

関連する実験動画

Last Updated: Jan 13, 2026

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

11.4K
Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 28, 2007

7.9K
Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

8.8K

科学分野:

  • 微生物学
  • 免疫学
  • 分子生物学

背景:

  • コレラ菌O1はコレラのパンデミックを引き起こします。
  • コレラ菌O1株は、小川株と稲葉株の血清型によって特徴付けられます。
  • 血清型の切り替わりは、病原体の適応と免疫圧に関連しています。

研究 の 目的:

  • O1抗原メチル化がコレラ菌の病原性に及ぼす影響を調査すること。
  • アイソジェニックな小川株と稲葉株のコレラ菌O1株を比較すること。
  • 血清型がコレラ菌のコロニー形成と感染性に果たす役割を解明すること。

主な方法:

  • アイソジェニックな小川株と稲葉株のコレラ菌O1臨床分離株を使用しました。
  • 細菌のコロニー形成、感染性、および抗菌ペプチドに対する耐性を評価しました。
  • O1抗原メチル化がコレラ菌の生存に及ぼす影響を調査しました。

主要な成果:

  • 小川株におけるO1抗原メチル化は、コレラ菌のコロニー形成を著しく促進します。
  • 小川株は、稲葉株と比較して感染性が高くなります。
  • メチル化は、陽イオン性抗菌ペプチドに対する耐性を付与します。

結論:

  • O1抗原メチル化は、コレラ菌のコロニー形成と感染性にとって重要です。
  • メチル化は、小腸における抗菌ペプチドからコレラ菌を保護します。
  • これらの発見は、コレラ菌O1血清型の生物学的意義を強調しています。