HDAC8分解PROTACの治療的可能性の解明：進捗、課題、および将来の方向性
Suvankar Banerjee1,2, Nilanjan Adhikari1, Balaram Ghosh3
1Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University Kolkata India nilanjan_juphar@rediffmail.com.
RSC medicinal chemistry
|January 7, 2026
まとめ
プロテオリシス標的キメラ（PROTAC）は、がんおよび神経変性疾患の標的であるヒストンデアセチラーゼ8（HDAC8）を正確に分解する方法を提供する。HDAC8-PROTACは高い効力と抗増殖効果を示し、治療開発の改善を示唆している。
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