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UV–Vis Spectrum

UV–Vis Spectrum

When light passes through a substance, a portion of the light is absorbed while the remaining light is reflected or transmitted. If the molecule absorbs light between the wavelengths of 180–400 nm range, the UV spectrum is obtained, and if it absorbs light in the 400–780 nm wavelength range, the visible spectrum is obtained.
The UV–Vis spectrum of a molecule is the plot of its absorbance versus wavelength. The plot is drawn by taking molar...

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material, molecules absorb light depending on the energy required for...

UV–Vis Spectrometers

UV–Vis Spectrometers

The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.

Nucleotide Excision Repair

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

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関連する実験動画

Updated: Jan 13, 2026

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

ナローバンドUVB（NB-UVB）最小紅斑量（MED）の基準範囲

Ewan Eadie¹, Brian Todd¹, Sanchez Luzvminda²

¹NHS Tayside, Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK.

Clinical and experimental dermatology

|January 7, 2026

まとめ

ナローバンドUVB（NB-UVB）光線療法における最小紅斑量（MED）検査では、肌タイプや部位によるばらつきが見られた。特に肌の色が濃いタイプでは、治療を最適化するために、最新のMED範囲の更新が必要である。

キーワード:

ナローバンドUVB 最小紅斑量光線療法 Fitzpatrick皮膚光型分類皮膚科光線生物学

さらに関連する動画

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

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関連する実験動画

Last Updated: Jan 13, 2026

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

科学分野:

皮膚科; 光線生物学; 臨床研究

背景:

ナローバンドUVB（NB-UVB）光線療法は、皮膚疾患の標準的な治療法である。最小紅斑量（MED）検査は、最適なNB-UVB線量決定および光線過敏症の特定に不可欠である。 MED値のばらつきは、治療効果と安全性に影響を与える可能性がある。

研究の目的:

ナローバンドUVB（NB-UVB）光線療法を受けている2つの異なる患者コホートからの最小紅斑量（MED）値を分析および比較する。 MED値とFitzpatrick皮膚光型分類（SPT）の関係を調査する。 NB-UVB MED検査の最新の基準範囲を設定し、臨床診療に情報を提供する。

主な方法:

Dundeeの882人、Londonの188人の患者からのMED値の後ろ向き分析。異常な光線過敏症または再検査MEDを受けた患者を除外した。異なるFitzpatrick皮膚光型分類（SPT）間および2つの研究センター間でのMED値の統計的比較。

主要な成果:

中央値MED値は、Fitzpatrick皮膚光型分類（SPT）が高いほど一般的に増加したが、有意な重複が観察された。 Dundeeコホートは、SPT II/IIIにおいてLondonコホートと比較して統計的に低いMED値を示した。以前のボランティア研究と比較して低いMED値が報告され、SPT IV-VIでは非応答者の割合が高かった。

結論:

NB-UVB光線療法の既存のMED値は、センター間のばらつきを示しており、最新の基準範囲の更新が必要である。現在の検査プロトコルは、非応答者の割合が高いことを考慮して、特に肌の色が濃いタイプ（SPT IV-VI）の個人に合わせて調整する必要がある可能性がある。これらの発見は、患者のアウトカムを改善するためにNB-UVB光線療法プロトコルを洗練することを支持する。