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Updated: Jan 13, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

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Published on: June 18, 2020

昇圧された血管作動性腸管ペプチド濃度はVIPomaをほとんど予測しない

Jack Korleski¹, Luis E Ospina Velasquez², Joshua Bornhorst³

¹Department of Internal Medicine, Mayo Clinic, Rochester MN United States.

Endocrine-related cancer

|January 7, 2026

Abstract:

VIPoma is a rare neuroendocrine tumor (NET) that is challenging to diagnose. While VIP concentrations are elevated in VIPoma, the optimal threshold for diagnostic purposes is not well defined. We aimed to study this in a single institution population. We obtained results from vasoactive intestinal peptide (VIP) tests from 2011-2023 and reviewed the medical record for patients who had concentrations greater than our established assay-specific reference limit of 75 pg/mL. We compared plasma VIP concentrations between patient cohorts with and without VIPoma and determined the optimal threshold for VIP concentrations to predict a VIPoma in this population.76 patients met the selection criteria. Of these, nine cases of VIPoma were diagnosed. All patients had chronic diarrhea, and five patients had a previous diagnosis of a pancreatic neuroendocrine tumor (PNET). VIP concentrations drawn for acute/episodic diarrhea or flushing/diaphoresis did not lead to a diagnosis of a VIPoma. Mean VIP concentration was increased in patients with a VIPoma relative to those without, but the difference was not statistically significant (508 pg/mL vs 223 pg/mL, p=0.31). Using the threshold of 75 pg/mL, the positive predictive value for a VIPoma was 12%. The optimal VIP threshold was 442 pg/mL (OR: 11.96, 95% CI: 2.00-79.69, p=0.01) with statistically significant odds ratios starting at 200 pg/mL. Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. We recommend that VIP only be drawn in certain clinical scenarios to avoid unnecessary medical investigations.

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