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Updated: Jan 13, 2026

Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion

Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion

Published on: September 13, 2024

ウイルスと宿主レプリソーム：小型DNA腫瘍ウイルスの発がんメカニズムの解明

Christopher D Collins^1,2,3, Matthew Stefely², Kavi Prem Milan Mehta⁴

¹John W. and Jeanne M. Rowe Center for Research in Virology, Madison, Wisconsin, USA.

Journal of virology

|January 7, 2026

Abstract:

Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) are DNA tumor viruses that cause human cancer. The mechanisms by which HPV and MCPyV oncoproteins induce genomic instability are not well defined. This minireview discusses the influence of these oncoproteins on the repertoire of proteins at replicating DNA, known as the host replisome, and discusses how new technologies like isolation of proteins on nascent DNA (iPOND) can drive the discovery of viral dysregulation of the host replisome to enhance our understanding of viral oncogenesis.

キーワード:

DNA損傷 DNA損傷修復 DNA複製 DNA腫瘍ウイルスマーケル細胞多瘤ウイルス宿主レプリソームヒトパピローマウイルス iPOND ウイルス腫瘍遺伝子産物

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Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Published on: July 26, 2024

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