マイクロ生理学的システムとしてのリンパ管チップ：in vitroでのリンパ管構造と機能の工学的再構築
1Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA. el767@cornell.edu.
Lab on a chip
|January 7, 2026
まとめ
オルガノイド・オン・チップ技術によりリンパ系研究が進歩しています。これらのマイクロ流体システムは、疾患の理解と創薬のためにヒトのリンパ機能により良く適合します。
関連する概念動画
01:16Lymphatic Vessels and Lymph Transport
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
01:15Development of the Lymphatic System
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...