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Improving Translational Accuracy02:07

Improving Translational Accuracy

14.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Improving Translational Accuracy02:07

Improving Translational Accuracy

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Language Development01:22

Language Development

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Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
831
Language and Cognition01:27

Language and Cognition

704
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
704
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

3.4K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
3.4K
Language01:16

Language

876
Language is a unique communication system that uses words and systematic rules to organize and transmit information. Unlike other forms of communication, which may involve postures, movements, odors, or vocalizations, language relies on symbols and grammar. This makes human communication distinct from that of other species, who also communicate but do not use language in the same way humans do.
Corballis and Suddendorf (2007) and Tomasello and Rakoczy (2003) highlight the role of language in...
876

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Updated: Jan 13, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
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大規模言語モデルにおけるペルソナシフトが臨床行動閾値に与える影響

Eyal Klang1,2, Alon Gorenstein1,2, Mahmud Omar1,2

  • 1The Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, NY, USA.

medRxiv : the preprint server for health sciences
|January 8, 2026
PubMed
まとめ

システムプロンプトは、同一の患者データであっても、大規模言語モデル(LLM)における臨床的意思決定を大幅に変更します。これは、LLMプロンプトを展開構成として規制する必要があることを強調しています。

キーワード:
バイアス認知倫理大規模言語モデル患者安全トランスフォーマー

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