関連する実験動画
Updated: Jan 13, 2026

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
トルコ小児集団におけるCobas分析装置を用いたPT、INRおよびAPTT検査の基準範囲
Berrak Guven1, Ismail Benice1, Bilgehan Acikgoz2
1Department of Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.
Abstract:
The aim of this study was to establish reference intervals (RIs) for prothrombin time (PT), international normalized ratio (INR) and activated partial thromboplastin time (APTT) in the Turkish pediatric population using the Cobas t511 analyzer. This retrospective study included preoperative laboratory results from 1065 healthy pediatric patients (aged 0-18 years) who underwent minor elective surgeries. RIs were established following Clinical and Laboratory Standards Institute (CLSI) guidelines and were summarized as 2.5th-97.5th percentile reference limits using nonparametric approach. The overall median (95% RI) values were 9.0 s [8.1-10.5] for PT, 1.02 [0.93-1.17] for INR, and 29.7 s [24.3-35.2] for APTT. Statistically significant differences were observed in PT, INR and APTT across age groups (p < 0.001). Accordingly, data were stratified into 18 age partitions, and reported for each group. In conclusion, our study provides pediatric-specific RIs for PT, INR and APTT using the Cobas t511 analyzer in a Turkish cohort. These age-stratified intervals can improve the interpretation of coagulation tests in clinical practice and contribute to more accurate pediatric diagnostics.
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