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Updated: Jan 13, 2026

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse

Published on: September 12, 2018

心臓腫瘍学における可溶性ネプリライシンとトランスレーショナル連続体

Massimiliano Camilli^1,2, Antonio Abbate³

¹Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy. massimiliano.camilli91@gmail.com.

Cardio-oncology (London, England)

|January 8, 2026

Abstract:

In cardio-oncology, the gap between mechanistic studies and pharmacological trials impedes the delineation of effective cardioprotective strategies. The angiotensin-receptor/neprilysin inhibitor (ARNI) have shown beneficial effects in patients with heart failure with reduced ejection fraction, but failed to show significant benefit in cardio-oncology. In a preclinical model, soluble neprilysin levels (sNEP) tracked anthracycline-induced myocardial damage and systolic dysfunction and sNEP levels may predict benefits of ARNI. The neutral results of clinical trials testing sacubitril/valsartan in this setting underscore the challenge of bridging pre-clinical knowledge to patients' management and call for clinical trials in precision medicine approaches in which biomarkers (i.e. sNEP) may guide treatment (i.e. ARNI).

キーワード:

心臓腫瘍学研究展望サクビトリル/バルサルタン可溶性ネプリライシントランスレーショナル心臓病学

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Translating Ribosome Affinity Purification TRAP for RNA Isolation from Endothelial Cells In Vivo

Translating Ribosome Affinity Purification TRAP for RNA Isolation from Endothelial Cells In Vivo

Published on: May 25, 2019

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