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Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

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活動性ループス腎炎における脈絡膜の厚さ

Letícia Maria Kolachinski Raposo Brandão1, Lucas Parente de Andrade2, Débora Cordeiro do Rosário1

  • 1Division of Rheumatology, Faculdade de Medicina, Hospital Das Clínicas, Universidade de São Paulo, São Paulo, Brazil.

Lupus
|January 9, 2026
PubMed
まとめ

活動性ループス腎炎（LN）患者は脈絡膜の厚さ（CT）が減少しています。この所見は、脈絡膜がLNにおける亜臨床的な標的臓器であることを示唆しており、CTは疾患活動性を非侵襲的に監視するのに役立つ可能性があります。

キーワード:
活動性ループス腎炎脈絡膜光干渉断層計

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科学分野:

  • 眼科学
  • 腎臓病学
  • リウマチ学

背景:

  • ループス脈絡膜症は、重度の全身性エリテマトーデス（SLE）活動およびループス腎炎（LN）に関連しています。
  • 脈絡膜厚（CT）と腎糸球体血管障害またはLN活動との関係は、議論の余地があります。
  • この研究では、治療前の活動性LN患者におけるCTを調査します。

研究 の 目的:

  • 活動性ループス腎炎（LN）患者における脈絡膜厚（CT）を評価すること。
  • 活動性LN患者と健康な対照群とのCTを比較すること。
  • LN活動の指標としてのCTを調査すること。

主な方法:

  • 28人の活動性LN患者および健康な対照者を含む、症例対照横断研究。
  • 患者はSLEの2019 ACR/EULAR基準を満たしました。
  • 20人の患者で腎生検によりLNが確認されました。
  • 脈絡膜厚（CT）は、スペクトル領域光干渉断層計（SD-OCT）を使用して測定されました。

主要な成果:

  • LN患者と対照群は、年齢と性別の分布が同様でした。
  • LN患者は対照群と比較して、中心窩下中心脈絡膜厚が有意に低かった（329±69.9μm対297±41.7μm、p=0.004）。
  • 腎臓のパラメータは、クレアチニンのメディアンが0.80±0.26 mg/dL、タンパク質/クレアチニン比が1.84±1.70 g/gでした。

結論:

  • 活動性LN患者における中心窩下中心CTの減少は、脈絡膜が全身性炎症の亜臨床的な標的臓器であることを示唆しています。
  • CT測定は、LN活動を監視するための有望な非侵襲的ツールです。
  • LN管理のバイオマーカーとしてのCTの有用性を確認するには、さらなる縦断的研究が必要です。