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Updated: Jan 13, 2026

Medium Preparation for the Cultivation of Microorganisms under Strictly Anaerobic/Anoxic Conditions

Medium Preparation for the Cultivation of Microorganisms under Strictly Anaerobic/Anoxic Conditions

Published on: August 15, 2019

モデルアセトゲンをCO₂駆動型バイオ生産のシャシーとして

Karen Rodriguez¹, Jitendra Joshi², Chris Greening³

¹Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.

Current opinion in biotechnology

|January 9, 2026

Abstract:

Microbes play a pivotal role in the Earth's carbon cycle, regulating greenhouse gas fluxes by emitting, fixing and transforming CO₂. Among them, acetogens stand out for their ability to fix CO₂ through the Wood-Ljungdahl pathway, an ancient, highly energy-efficient route to acetyl-CoA that operates at thermodynamic limits. By coupling hydrogen (H₂) or carbon monoxide oxidation to CO₂ fixation, acetogens conserve energy while generating biomass and valuable products such as ethanol and acetate. These features position them as promising microbial cell factories for sustainable bioproduction via gas fermentation. Recent advances in metabolic engineering and synthetic biology have expanded the production spectrum of acetogens, enabling production of platform chemicals at lab-to-commercial scale. Yet, CO₂-only bioconversion remains energetically challenging compared to syngas-based applications, requiring innovative solutions in strain development, bioprocess optimisation and integration of renewable energy sources. This review highlights the central role of model acetogens in anaerobic CO₂ conversion, covering their metabolic capabilities, strain development and emerging bioprocess strategies to unlock their potential for low-carbon biomanufacturing.

キーワード:

アセトゲン二酸化炭素固定ウッド・ラングダール経路バイオ生産低炭素製造

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