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Updated: Jan 13, 2026

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
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移植されたヒトニューロンによる損傷脳回路統合の転写コード

Zhifu Wang1, Danyi Zheng1, Shu-Min Chou1

  • 1Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore, Singapore.

Cell stem cell
|January 9, 2026
PubMed
まとめ

成人マウスに移植されたヒト皮質前駆細胞は、神経回路に正常に統合されました。この研究は、損傷した脳回路を修復するための軸索投射を導く転写コードを特定し、神経疾患の治療のための有望な戦略を提供します。

キーワード:
回路統合コード皮質脊髄路ヒト多能性幹細胞由来ニューロン神経回路統合神経移植神経疾患ニューロン置換脳卒中

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Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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