訓練されたILC2は、セロトニン依存性メカニズムを介して線虫感染中のIL-17関連肺傷害を防ぐ

Type 2 cytokinerelease promotes wound healing and helminth clearance, but it remains unclearwhethergroup 2 innate lymphocytes (ILC2s) and T-helper2 cells (T_H2) cells have functionally distinctroles during anamnestic immunity. This study demonstrates that ILC2 can prevent re-infection andlimit tissue injury caused by the helminthNippostrongylus brasiliensis (Nb). T_H2 cells were necessary during initial antigen encounter but dispensable forearly pathogen clearance and lungrepairafterILC2 priming. Upon re-infection, trained ILC2 selectively blocked interleukin (IL)-17+ γδT cell expansion and infection-induced lung injury through an Amphiregulin (Areg)-independent mechanism. Trained ILC2s had a distinct metabolic gene expression profile marked by elevated tryptophan hydroxylase 1(Tph1) and pulmonary serotonin levels were largely ILC2-dependent. Surprisingly, serotonin prevented IL-17-associated lung hemorrhage irrespective of parasite load. We propose that T_H2-ILC2 interactions drive pathogen control, but ILC2 distinctly control lung tissuerepairthrough serotonin.