MAP-Xがマラリア原虫の変幻自在な相互作用体を明らかに
1Key Laboratory of Livestock Infectious Diseases, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China.
Abstract:
Pazicky et al. introduced a thermal profiling method, meltome-assisted profiling of protein complexes (MAP-X), combined with machine learning, to map protein complex dynamics in intact Plasmodium falciparum, a deadly malaria parasite. This in situ approach reveals a highly dynamic interactome, identifying novel complexes and 'moonlighting' proteins, shifting our understanding from static lists to temporal networks.
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