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Updated: Jan 13, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

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部位特異的HPV18インテグレーションは、代謝再プログラミングによるSpHK1/S1P/S1PR1経路の機能不全を介して子宮頸癌発生を促進する

Liming Wang1, Xiaomin Li2, Ci Ren3

  • 1Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Cell death & disease
|January 9, 2026
PubMed
まとめ

高リスク型ヒトパピローマウイルスインテグレーションは、ゲノム構造を変化させ、がん関連遺伝子を活性化することにより、子宮頸がんを駆動する。スフィンゴシン-1-リン酸経路の標的化は腫瘍増殖を阻害し、新たな治療戦略を提供する。

キーワード:
子宮頸がんヒトパピローマウイルスゲノムインテグレーション代謝スフィンゴシン-1-リン酸

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