関連する実験動画
Updated: Jan 13, 2026

Animal Model of Implant-Associated Infections in Mice
Published on: June 27, 2025
免疫系の調節不全を再プログラムすることによるインプラント関連バイオフィルム感染症に対する新たな非抗生物質戦略
Yu Zhang1, Zhuo Dai1, Xiaoye Li1
1Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, Jiangsu, China.
Abstract:
Implant-associated infections (IAIs) arise from immune dysregulation and the resilience of bacterial biofilms, which create a permissive niche for persistent infection. Biofilms further suppress host immunity and impair repair. Advances in nanoengineered surfaces and multifunctional antimicrobial coatings, together with gas-releasing and stimulus-responsive nanoplatforms, offer effective non-antibiotic strategies to inhibit colonization, disrupt biofilms, and modulate local immunity. This review summarizes emerging immune-informed approaches for treating IAIs.
関連する概念動画
Biofilms
Bacterial Signaling
Gene Regulation in Microbial Communities: Quorum Sensing
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Microorganisms in Medicine and Therapeutics

