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関連する概念動画

Testosterone: Functions and Regulation01:26

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Chemical Signaling in the Endocrine System01:08

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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
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Regulation of Metabolism01:19

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
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Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
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Intracellular Hormone Receptors01:08

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Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
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代謝メッセンジャー：テストステロン

Franck Mauvais-Jarvis1,2, Shalender Bhasin3

  • 1Hormone Therapy Clinic, Medicine Service, Southeast Louisiana New Orleans VA Medical Center, New Orleans, LA, USA. fmauvais@tulane.edu.

Nature metabolism
|January 9, 2026
PubMed
まとめ
この要約は機械生成です。

テストステロンは、直接的および間接的に代謝を調節する両方の性別にとって重要なホルモンです。その発見と合成はホルモン補充療法に革命をもたらし、代謝恒常性の維持に不可欠であり続けています。

キーワード:
テストステロン代謝ホルモン補充療法恒常性

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科学分野:

  • 内分泌学
  • 代謝科学
  • ホルモン生物学

背景:

  • 1930年代に合成されたテストステロンは、補充療法に使用された最初​​のホルモンです。
  • アンドロゲン受容体（AR）を介して、またエストロゲンのプロホルモンとして機能します。
  • ジヒドロテストステロンなどのテストステロン代謝物も重要な役割を果たしています。

研究 の 目的:

  • テストステロンの発見と治療用途における歴史的マイルストーンをレビューすること。
  • テストステロンの代謝調節における役割に関する現在の知識を統合すること。
  • 代謝恒常性の維持におけるテストステロンの重要性を強調すること。

主な方法:

  • テストステロンの発見とその応用の歴史的レビュー。
  • テストステロンの代謝機能に関する前臨床およびヒトでの研究の合成。
  • アンドロゲンおよびエストロゲン受容体を含むシグナル伝達経路の分析。

主要な成果:

  • テストステロンは、直接的および間接的な経路を通じて代謝に影響を与えます。
  • エストラジオールやジヒドロテストステロンなどの代謝物は、重要なメディエーターです。
  • テストステロンとその代謝物のゲノムおよび非ゲノム作用が関与しています。

結論:

  • テストステロンは、男性と女性の両方の代謝恒常性に不可欠です。
  • テストステロンの多面的な役割を理解することは、治療用途にとってcriticalです。
  • 継続的な研究により、テストステロンの全身的な代謝の重要性が明らかになり続けています。