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Updated: Jan 13, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

6.3K

ヒト神経分化における段階特異的オルタナティブポリadenylationをロングおよびショートリードシーケンシングの統合により明らかに

Zheqi Lou1, Xianyan Zeng1,2, Tinghui Jiang1

  • 1College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.

Biology
|January 10, 2026
PubMed
まとめ

本研究は、ヒト胚性幹細胞（hESC）神経分化におけるオルタナティブポリadenylation（APA）に関する新たな洞察を明らかにするものである。本研究では、数千もの新規転写産物およびポリ(A)サイトが同定され、細胞運命調節の理解が深まった。

キーワード:
Oxford Nanopore Technologiesオルタナティブポリadenylationエクソンオルタナティブポリadenylationヒト胚性幹細胞イントロニックオルタナティブポリadenylation神経分化ショートリードシーケンシング

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関連する概念動画

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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