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Updated: Jan 13, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

リポタンパク質(a)と大動脈弁狭窄症：病態生理から新たな薬理学的薬剤まで

Federica Agnello^1,2, Giulia Laterra^1,2, Lorenzo Scalia²

¹Faculty of Medicine and Surgery, Università degli Studi di Enna "Kore", Piazza dell'Università, 94100 Enna, Italy.

Journal of clinical medicine

|January 10, 2026

Abstract:

Aortic valve stenosis (AVS) is the most common valvular disease in developed countries, and no pharmacological therapy is currently available. Increasing evidence identifies lipoprotein(a) [Lp(a)] as a causal factor linking lipid metabolism, inflammation, and valve calcification. Lp(a) levels are largely genetically determined and remain stable throughout life, making them a potential therapeutic target. This review summarizes the current evidence on Lp(a) and AVS pathophysiology, the diagnostic and prognostic role of Lp(a), and the therapeutic potential of Lp(a)-lowering agents. Emerging Lp(a)-targeted therapies, including antisense oligonucleotides and siRNA-based agents, could reshape AVS management by providing the first pharmacological option to slow disease progression in selected high-risk patients.

キーワード:

Lp(a)PCSK9i 大動脈弁狭窄症アテローム性動脈硬化症スタチン

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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

Published on: March 31, 2023

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