関連する実験動画

Updated: May 12, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
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Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

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尿路上皮癌におけるグレードおよび病期分類の改善のためのKi-67およびE-カドヘリン閾値の最適化

Stefan Harsanyi1, Zuzana Varchulova Novakova1, Lucia Neuschlova1

  • 1Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovakia.

Journal of clinical medicine
|January 10, 2026
PubMed
まとめ

Ki-67は、膀胱癌の病期分類およびグレード分類において最も効果的な単一バイオマーカーです。Ki-67とE-カドヘリンの組み合わせは、非筋層浸潤性（NMIBC）対筋層浸潤性膀胱癌（MIBC）および低グレード（LG）対高グレード（HG）腫瘍の識別を強化します。

キーワード:
E-カドヘリンKi-67MIBCROC分析バイオマーカー膀胱癌カットオフ分析p53腫瘍グレード

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...