小児の多尿を伴う急性腎障害:システマティックレビュー
Giulio Rivetti1, Mariantonia Braile1, Anna Di Sessa1
1Department of Woman, Child and of General and Specialized Surgery, Università Degli Studi Della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138 Naples, Italy.
Journal of clinical medicine
|January 10, 2026
まとめ
急性腎障害(AKI)は、特に糖尿病性ケトアシドーシス(DKA)やその他の病状において、小児の多尿として現れることがあります。このレビューは、小児のAKIと多尿の提示に関する所見を統合したものです。
科学分野:
- 小児腎臓病学
- 集中治療医学
- 内分泌学
背景:
- 小児における急性腎障害(AKI)と多尿は、診断と管理の課題をもたらします。
- AKIと多尿の間の相互作用を理解することは、小児患者のケアにとって非常に重要です。
研究 の 目的:
- 多尿を経験している小児におけるAKIの提示を系統的にレビューおよび統合すること。
- 小児集団におけるAKIと多尿の併存に関連する根本的な状態を特定すること。
主な方法:
- Embase、PubMed、Scopusデータベースを横断する系統的文献検索。
- 小児AKIと多尿に焦点を当てた研究および症例報告の包含。
- 選択された出版物の方法論的品質評価。
主要な成果:
- 32人の小児患者(平均年齢11.02歳)のデータが分析されました。
- 多尿は26人の患者に見られ、糖尿病性ケトアシドーシス(DKA)が最も一般的な関連疾患でした(19例)。
- 多尿がありデータが利用可能な20人の患者のうち、9人(45%)がAKIを発症し、数人はKDIGOステージ3に達しました。
結論:
- 多尿は、小児におけるAKIの病態生理の不可欠な部分である可能性があります。
- DKAのような代謝性疾患、バーター症候群のような腎臓病学的な状態、神経芽腫を含む腫瘍学的な症例において、多尿と重度のAKI(KDIGOステージ≥2)との関連が観察されました。
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