関連する実験動画
Updated: Jan 13, 2026

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
睡眠時間と疾患有病率との間の因果関係の評価:メンデルランダム化研究の包括的な系統的レビューとメタアナリシス
Zhihui Wang1, Lingyu Yao2, Mengyue Tu3
1Department of Pediatrics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Background:
The causal link between sleep duration and diverse health conditions remains unconfirmed. This meta-analysis aimed to clarify these relationships by synthesizing Mendelian randomization (MR) study evidence.
Methods:
PubMed was systematically searched up to February 15, 2024, for MR studies exploring genetic predispositions to sleep duration/insomnia (short/long/overall sleep duration, insomnia) and associations with circulatory, digestive, neurodegenerative, metabolic diseases, and cancers. Eligible effect estimates were meta-analyzed.
Results:
Fifty-one MR studies were included. Genetic variations in sleep traits were strongly linked to elevated risk of 12 cardiovascular diseases, obesity-related metrics (Type 2 diabetes, fasting glucose/insulin, HbA1c), neurological disorders (Alzheimer, amyotrophic lateral sclerosis, Parkinson disease), mental health conditions (attention-deficit/hyperactivity disorder, autism, bipolar disorder, major depressive disorder, schizophrenia), inflammatory bowel disease, and lung cancer.
Conclusion:
Genetic evidence confirms causal associations between sleep characteristics and multiple diseases, emphasizing sleep's key role in health promotion and supporting personalized sleep management to reduce disease risk.
関連する概念動画
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Circadian Rhythms and Gene Regulation
Correlations
Causality in Epidemiology
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

