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Updated: May 5, 2026

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

心臓収縮調節デバイスとMicraリードレスペースメーカーの心臓収縮調節デバイスとMicraリードレスペースメーカーの併用移植におけるリードパラドックスの克服：症例報告

Gabriele Pavani^1,2,3,4, Paolo Garrone^1,3, Gianpaolo Varalda^1,3

¹Cardiac Electrophysiology Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.

Journal of cardiovascular electrophysiology

|January 10, 2026

要旨

Background:

Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) can lead to refractory heart failure. A "lead paradox" occurs when patients with a Micra leadless pacemaker require lead-based Cardiac Contractility Modulation (CCM) therapy.

Case Summary:

We detail the first co-implantation of CCM and Micra devices in a 78-year-old male with ATTRwt-CA and NYHA III heart failure. A multi-view fluoroscopic technique ensured spatial separation, while specific device programming mitigated electrical crosstalk post-procedure.

Conclusion:

At 1 year, the patient stabilized to NYHA Class II without further hospitalizations. This dual-device strategy is a feasible and safe technical roadmap for this complex clinical problem.

キーワード:

心臓収縮調節心臓アミロイドーシス症例報告デバイス間相互作用電気生理学的技術リードレスペースメーカー

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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Published on: March 30, 2022

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