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Updated: Jan 13, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

スタチンの多面的効果：炎症、酸化ストレス、免疫調節に焦点を当てる（パートI）

Ali Mahmoudi¹, Niki Katsiki^2,3, Michal Vrablik⁴

¹Department of Basic Medical Sciences, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran.

Current atherosclerosis reports

|January 10, 2026

要旨

Purpose Of Review:

Statins are the most widely prescribed class of drugs for cardiovascular (CV) disease (CVD) prevention due to their potent lipid-lowering effects. However, accumulating evidence demonstrates additional cardioprotective properties of statins mediated through pleiotropic mechanisms unrelated to cholesterol modulation. We aimed to discuss the pleiotropic effects of statins and their relevance to clinical outcomes in 2 reviews: Part I focuses on anti-inflammatory, antioxidant and immunomodulatory effects of statins, whereas Part II on statin-induced endothelial function improvement, plaque stabilization and anti-thrombotic effects. Part II also includes a clinical applications and future directions section.

Recent Findings:

A literature search was conducted in Embase, Scopus, web of science, PubMed and Cochrane Library databases for experimental and clinical studies investigating the effects of statins on inflammation, oxidative stress and immune function. Statins exert potent anti-inflammatory, antioxidant and immunomodulatory activities that can be linked to reduced CV events. Statins confer cardio protection via diverse pleiotropic pathways distinct from cholesterol modulation. Future directions involve optimizing regimens to maximize clinical benefits, addressing controversies, and exploring statins' therapeutic potential beyond CVD through non-lipid mechanisms. A comprehensive understanding of statins' pleiotropic profile will uncover new preventive strategies and therapeutic applications.

キーワード:

抗炎症抗酸化心血管疾患免疫調節多面的効果スタチン

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