高強度集束超音波による術後免疫療法の増強におけるマンガン系金属有機構造体

Limited antigen presentation renders high-intensity focused ultrasound (HIFU)-triggered immune response insufficient to improve prognosis. Herein, manganese-based metal-organic frameworks (termed AMS MOFs) were designed to co-deliver hypoxia-activated prodrug banoxantrone (AQ4N) and stimulator of interferon genes (STING) agonist SR-717, for enhancing antigen presentation-related postoperative immunotherapy. Under hypoxic microenvironment after HIFU surgery, the released AQ4N initiated immunogenic cell death causing the release of danger-associated molecular patterns. Simultaneously, SR-717 activated STING pathway and together with Mn²⁺-promoted the binding affinity of cGAMP-STING, finally eliciting robust type I interferon response. The synergism of these processes consequently promoted immune responses relevant to tumor antigen presentation and inhibited breast tumor recurrence and metastasis. This study presents a strategy for improving the overall prognosis of all surgery including HIFU.