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Updated: Jan 13, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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扁桃体癌におけるDIAMOND：シスプラチンは不要か？

Emma R Y Zhang¹, Ya Juan Zhou², Melvin L K Chua³

¹Division of Medical Sciences, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583, Singapore; Department of Mathematics, University of California, Los Angeles, 520 Portola Plaza, MS 6363, Los Angeles, CA 90095-1555, USA.

Med (New York, N.Y.)

|January 10, 2026

Abstract:

The phase 3 DIAMOND trial conducted in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) reported comparable 3-year failure-free survival rates between a cisplatin-containing versus a cisplatin-free regimen with radiotherapy, in the backbone of induction, concurrent, and adjuvant anti-programmed death-1 (anti-PD-1) therapy.¹ Reduced cisplatin-related emesis also improved quality of life. DIAMOND challenges the conventional dogma of concurrent cisplatin-radiotherapy in the treatment of LA-NPC.

キーワード:

扁桃体癌シスプラチン抗PD-1療法第III相試験生活の質

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